主持人介绍



姚军

姚军,博士,教授。1997年获得The University of Illinois at Chicago博士学位,后作为研究员任职于美国辉瑞公司,合成化学公司等。2002年回国,在河北科技大学化学与制药工程学院从事教学和科研工作,为药物化学专业学术带头人。

研究方向:

新药开发,药物中间体工艺研究,不对称合成

教学工作经历

1.英语教学及双语教学。课程包括:波谱解析,药物化学,专业英语。

2.讲授本科生和研究生课程。课程包括:药物化学,天然药物化学,波谱解析,专业英语等。

3.主讲的《波谱解析》课程获得“2009年度河北科技大学校级精品课程”。另外,主讲的《波谱解析》课程曾经获得“2005年度河北省省级精品课程”和“河北科技大学校级精品课程”。

纵向科研课题 (2003年以来)

1.2009年河北省科技厅课题:“国家一类创新药物手性富马酸比索洛尔的制备”,课题编号:09276410D,主持人。

2.2006年河北省科技厅课题:“4-溴-N,N-二甲基苯胺生产新工艺”。项目编号:06215616,主持人。

3.2005年国家教育部项目:“桦木酸衍生物的制备”。教外司留[2005]383号,主持人。

4.2004年国家人事部项目:“药物控制释放材料聚酸酐的合成及其制剂研究”。国人部发[2004]99号,主持人。

5.2004年石家庄市科技局项目:“桂利嗪口腔崩解片的研究”。课题编号:2004423,主研人。

6.2004年国家自然科学基金项目:“抗肿瘤先导化合物Sansalvamide A 环肽及其相关物的设计合成”,项目批准号:30472074,主研人。

横向科研课题

2003年以来共计12项,合计科研经费200余万元。

例如:北京紫竹药业有限公司:“左炔诺孕酮杂质的合成及结构鉴定”,主持人,研究经费28万元。

科研成果

1.河北省科技厅课题“4-溴-N,N-二甲基苯胺生产新工艺”,国内领先水平。证书编号:20072269-1,主持人

2.河北省科技厅课题“桦木醇的提取和桦木酸的制备工艺研究”,国内领先水平,证书编号:20060118-1,主持人

3.河北省教育厅科学研究计划项目:“定向药物控制释放材料聚酸酐合成及缓释药物制剂的研究”,国际先进水平。证书编号:20060119-1,主持人

专利

共计申请21项国家发明专利。

例如:“手性芳氧丙醇胺类化合物及其盐的合成方法”,专利申请号200810055473.6(公开号:CN101323580A)。

发表文章

在Biochemistry等杂志发表论文共计26篇。

如:Mock, William; Yao, Jun; "Kinetic Characterization of the Serralysins: A Divergent Catalytic Mechanism Pertaining to Astacin-type Metalloproteases", Biochemistry 1997, 36: 4949-4958

其它荣誉

1.河北省高级评审委员会评委

2.河北省履行“禁止化学武器公约”技术专家

3.石家庄市反恐专家

Professor YAO Jun obtained his Ph.D. degree from the University of Illinois at Chicago (USA) in 1997. He had been worked in Pfizer, SynChem as a research investigator for over 4 years, and came back China in 2002. As a leader of medicinal chemistry, Dr. Yao has been working in the College of Chemical and Pharmaceutical Engineering at Hebei University of Science and Technology.

Research areas

New drug discovery, synthesis of drug intermediates, asymmetric synthesis

Teaching experiences

1.Courses in English and bilingual, include: spectrum elucidation, medicinal chemistry, and professional English.

2.Courses for undergraduate and graduate students. Main courses: medicinal chemistry, medicinal chemistry for natural products, spectrum elucidation, professional English.

3.Spectrum elucidation course was selected as excellent quality courses and curriculum by the Hebei University of Science and Technology in 2009. This course was also appraised as excellent quality courses and curriculum by the Hebei University of Science and Technology and Hebei Province in 2005.

Research projects from government (from the year of 2003)

1.Project funded by the Ministry of Science and Technology of Hebei province in 2009. “Preparation of Chiral Bisoprolol of 1st Class New Drug”. Project Number 09276410D, principle investigator.

2.Project funded by the Ministry of Science and Technology of Hebei province in 2006. “New Synthesis Method for 4-bromo-N,N-dimethylbenzenamine”. Project Number 06215616, principle investigator.

3.Project funded by the Ministry of Education in 2005. “Preparation the Derivatives of Betulinic Acid”, Project Number [2005]383, principle investigator.

4.Project funded by the Ministry of Human Resource in 2004, “Study on Synthesis and Preparation of Drug Controlled Material Polyanhydride”, Project Number [2004]99, principle investigator.

5.Project funded by the Bureau of Science and Technology in Shijiazhuang in 2004, “Study on Cinnarizine Orally Disintegrating Tablets”, Project Number [2004]99, main investigator.

6.Project funded by the National Natural Science Foundation in 2004, “The rational Design and Synthesis of Antitumor Cyclopeptide of Sansalvamide A and its Derivatives”, Project Number 30472074, main investigator.

Research projects from enterprise

Total of 12 projects have been finished since 2003, with research fund over 2 million Yuan.

For example: Project funded by Beijing Zizhu Pharmaceutical Corporation Ltd., “Synthesis and Identification of the Levonorgestrel Impurities”, main investigator.

Scientific Research Achievements

1.“New Synthesis Method for 4-bromo-N,N-dimethylbenzenamine”, Project from the Ministry of Science and Technology of Hebei province. National distinguished technology, Certificate Number: 20072269-1, principle investigator

2.“Preparation the Derivatives of Betulinic Acid”, Project from the Ministry of Science and Technology of Hebei province. National distinguished technology, Certificate Number: 20060118-1, principle investigator

3.“Study on Synthesis and Preparation of Drug Controlled Material Polyanhydride”, Project from the Ministry of Education of Hebei province, International advanced technology, Certificate Number: 20060119-1, principle investigator.

Patents

Total of 21 patents

For example: “Method for synthesizing chiral aryloxy propanolamine compounds and salts”. Yao, Jun; Song, Wei; Zhu, Jiangling. Faming Zhuanli Shenqing Gongkai Shuomingshu (2008, CN101323580A)

Publications

Published total of 26 papers on professional journals, like Biochemistry.

For example: Mock, William; Yao, Jun; "Kinetic Characterization of the Serralysins: A Divergent Catalytic Mechanism Pertaining to Astacin-type Metalloproteases", Biochemistry 1997, 36: 4949-4958

Other honors

1.Specialist of specialty and technology in posting advanced credentials of evaluation committee in Hebei

2.China Specialist of the Organization for the Prohibition of Chemical Weapons (OPCW)

3.Specialist for anti-terrorism in Shijiazhuang, Hebei